posted by: Jonathan Shaw
Yes. There was a spurt of media coverage this week into the success of a chlamydia vaccine trial. The NHS media feed, the Guardian, and the BBC were some of many outlets promoting the success. The full publication from the Lancet Infectious Diseases is available here.
This was an early phase “first-in-human” clinical trial. It studied just 40 women aged 19-45 years. The trial was assessing whether some new vaccines could promote an immune response (antibodies) against chlamydia. This is how vaccines work. You trick the immune system into thinking you have the infection and the body responds. The theory is then that the body will remember how to respond, and find it easier to fight the infection next time.
Unfortunately not. It is important to remember these early studies are to get some initial signals only. The first is to check that the vaccine is safe ie. doesn’t harm the women receiving them. The second is that the immune system actually responds to the vaccines and produces the antibodies.
The vaccine then needs to go on a longer journey, taking years. It needs to be tested in larger numbers of people to see if it remains safe, but most importantly to see if these antibodies actually reduce your chance of catching chlamydia. Just having the antibodies there doesn’t mean you are protected. This is important as we know that catching chlamydia once doesn’t protect you against being infected again in the future.
We recommend starting with these key components of good sexual health:
Testing is strongly recommended for anyone who has caught chlamydia, ideally 3 months after completing treatment. This is not because we are worried the treatment doesn’t work. It is because large numbers of people are infected again.
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